Cape Town - South Africa has three participants in the men's main draws at the Federer falls into Djokovic's half of US Open draw
Lloyd Harris is the other South African participating in the men's singles. He is currently the world No 99, but has made great strides this year by qualifying for the main draws of all the Grand Slam events.
The 22-year-old had a career-high ranking of 82 last month and will face a yet-to-be-determined qualifier in his US Open first round so will fancy his chances of advancing.
In in the men's doubles, South Africa's Raven Klaasen and his New Zealand partner Michael Venus are expected to go deep into the tournament.
While the doubles draw is yet to be announced, Klaasen (world No 8) and Venus (world No 9) are the third seeds.
At the most recent Grand Slam at Wimbledon, the duo made it to the semi-finals.
Meanwhile, in the wheelchair event that starts on September 5, Kgothatso Montjane will again be featuring.
Montjane, the first African wheelchair tennis player to play at all four Grand Slams, was also a semi-finalist in London and will look at yet another impressive showing in a fortnight's time.